The aim of the study was to identify ethnic differences in the number of CAG repeats of the androgen receptor gene (AR), anthropometric and hormonal indicators in men of three ethnic groups (Slavs, Buryats and Yakuts) living in the Russa. The androgen receptor mediates the effects of androgens on a wide range of organs and tissues in men. The AR is characterized by polymorphism of CAG repeats, which can be an ethno-dependent trait and determine functional and morphogenetic effects of testosterone. The study established the ethnic differences in the length of CAG repeats between the Slavs, Buryats and Yakuts (23, 24, 25 triplets, respectively), as well as in anthropometric and hormonal indicators. LH concentrations were higher in Buryats than in Slavs or Yakuts, but the testosterone level was the lowest in Buryats compared to Slavs or Yakuts.
androgen receptor, CAG repeats, testosterone, ethnicity
1. Davey R.A., Grossman M. Androgen receptor structure, function and biology: from bench to bedside // Crib. Biochem. Rev. 2016. V. 37. № 1. P. 3-15.
2. Xiao F, Lan A, Lin Z, et al. Impact of CAG repeat length in the androgen receptor gene on male infertility - a meta-analysis // Reprod. Biomed. Online. 2016. V. 33. № 1. P. 39-49.
3. Giagulli V.A., Carbone M.D., De Pergola G., et al. Could androgen receptor gene CAT tract polymorphism affect spermatogenesis in men with idiopathic infertility? // Y. Assist. Reprod. Genet. 2014. V. 31. No. 6. P. 689-697.
4. Krausz C., Riera-Escamilla A. Genetics of male infertility // Nat. Rev. Ural. 2018. V. 15. No. 6. P. 369-384.
5. Osadchuk L.V., Osadchuk A.V. The role of CAG and GCC gene polymorphism androgen receptors in male fertility. Genetics. 2022. Vol. 58. No. 3. pp. 247-266.
